A Novel Risk Assessment Model for Prefabricated Building Construction Based on Combination Weight and Catastrophe Progression Method

To reduce the construction risk of prefabricated building projects, a prefabricated building construction risk assessment index system with five first-level indicators and 21 second-level indicators was established based on human, machine, material, management, and environmental factors. By combining the analytic hierarchy process (AHP), CRiteria Importance through Intercriteria Correlation (CRITIC), and catastrophe theory, a risk assessment model of prefabricated building construction based on a combination weighting and catastrophe progression method was constructed. The effectiveness of the assessment model using the combination weighting and catastrophe progression method was verified through case analysis. The results show the following: (1) The quality of the prefabricated components, the standardization degree of the prefabricated components, and the environment of the installation working space in the construction risk assessment indicators of prefabricated buildings obtained by the AHP-CRITIC weighting method have higher weights. (2) Four prefabricated construction enterprises under China State Construction Corporation are evaluated, and the evaluation results effectively evaluate the project risk situation before an accident occurred, achieving the goal of improving the risk management efficiency. (3) The AHP-CRITIC weighting method can reflect the fuzziness of the construction risk of the evaluated project, effectively reduce information loss, and thus make the evaluation results more accurate. The conclusions have important practical significance for improving the construction risk management of prefabricated buildings

HYPERMETHYLATED DNA AS BIOMARKER FOR NASOPHARYNGEAL CANCER DETECTION

Backgroud: Nasopharyngeal carcinoma (NPC) is a malignancy with remarkable geographic and distribution worldwide, toward in Southern China and Southern Asia. In addition to Epstein–Barr virus infection, environmental carcinogens, the development of NPC involves the cumulative genetic as well as epigenetic alteration. More recently, it has been reported that DNA hypermethylation, an epigenetic mechanism, that occurred by the addition of a methyl group at 5' position of the pyrimidine ring of cytosine residues at CpG islands, has been considered as the cause of nasopharyngeal tumorigenesis. In recent years, many reports have focused on the identification, evaluation of aberrant methylation of target tumor suppressor genes' promoters, such as RASSF1A, BLU, DLEC, RARβ, p16, p15, p14, and MGMT in the NPC development.Objective: We focused on the description and exemplification of the DNA hypermethylation changes in nasopharyngeal carcinoma.Conclusion: we highlighted the DNA hypermethylation as a potential biomarker applied in monitoring, screening, and early diagnosis for cancer of nasopharynx

ENRICHMENT, ISOLATION AND CHARACTERIZATION OF CHEMOLITHOAUTOTROPHIC ARSENITE OXIDIZING BACTERIA FOR REMOVAL OF ARSENIC FROM WATER PHASE

L. Nguyen Ai, A. Sato, D. Inoue, K. Sei, S. Soda, M. Ike,Enrichment of arsenite oxidizing bacteria under autotrophic conditions and the isolation and characterization of facultative chemolithoautotrophic arsenite oxidizing bacteria for removal of arsenic from groundwater, Water Science and Technology: Water Supply, vol. 12, no. 5, pp. 707-714, 2012Nguyen Ai Lea, Akiko Satoa, Daisuke Inouea, b,Kazunari Seia, b, Satoshi Sodaa, Michihiko Ike, Bacterial community succession during the enrichment of chemolithoautotrophic arsenite oxidizing bacteria at high arsenic concentrations, Journal of Environmental Sciences, vol. 24, no. 12, pp. 2133–2140, 2012

Epidemiology, incidence and mortality of Nasopharynx Cancer in Southeast Asia: an update report

Background: Nasopharyngeal cancer, with a distinct geographical and racial distribution, is the common neck and head cancer. Knowledge about the ecological factors including incidence, mortality, and so on, is important to find out the best way for its prevention in future. The aim of current study was to find out the incidence(-ASR), mortality(-ASR) of nasopharyngeal cancer and its correlation between those factors with HDI as well as its components in Southeast Asian countries in 2018.Methods: The data of the incidence(-ASR), mortality(-ASR), Human development index (HDI) were extracted from the GLOBOCAN project and Human Development Reports database. The relationships were evaluated by using Pearson Correlation Coefficient method.Results: In Southeast Asian region, incidence of 34,681, and mortality of 22,231 were recorded. The high incidence and mortality were related to medium human development countries. The significant positive correlations were observed between HDI with incidence-ASR (r = 6.25, p = 0.04) and mortality-ASR (r = 0.38, p = 0.26). No significant correlations were found between HDI component with incidence-ASR and mortality-ASR, except for the relationship between incidence-ASR and GNI/capita (r = 0.71, p = 0.02).Conclusion: The nasopharyngeal cancer is native to Asian region, includes Southeast Asian countries. The highest incidence and mortality were recorded in medium HDI countries.Keywords: Nasopharyngeal cancer; Epidemiology; Ecology, Southeast Asi

ASSESSING CONSUMER BEHAVIOR TOWARDS FISH SAUCE PRODUCTS BY USING FOOD CHOICE QUESTIONNAIRE

This study aims to assess Vietnamese consumer behavior towards fish sauce product. It consists of two experiments. In the first experiment, consumer concept was explored using word association method. It was performed on 300 Vietnamese consumers with the prompt word as “fish sauce”. The data were analyzed by a triangulation method. The results evoke six factors associated with fish sauce as Sensory Appeal, Health, Price, Convenience, Traditional Value, Quality and Safety. These findings were the starting point for a modification of food choice questionnaire (FCQ) adapted to fish sauce product. In the second experiment, the modified FCQ with 18 items was used to assess the consumer behavior. The survey was performed on 300 Vietnamese consumers. The data were analyzed by using Exploratory Factor Analysis and Confirmatory Factor Analysis. The obtained model with five factors was adapted to fish sauce for Vietnamese consumers ( = 1.67, GFI = 0.93, CFI = 0.92, RSME = 0.47). In this, Sensory Appeal is the most important factor which might affect consumer food choice motivations. We expect that these results will be useful for the local manufacturers who want to develop traditional food products and/or enlarge national market

Factors Affecting Prosocial Sharing Health-related Information on Social Media During a Health Crisis

During a health crisis, prosocial sharing of health-related information (HRI) on social media can help to deliver early warnings about new diseases, raise social awareness, exchange support, and spread health policies. Current literature has mainly focused on the factors of general sharing of HRI under normal conditions but neglected those motivations under the health crisis context. This research aims to investigate factors that influence online users’ prosocial sharing of HRI during a health crisis. To obtain the objective, this study developed a dual helping-protecting motivation model from the fear appeal model and social exchange theory. The partial least squares analysis, carried out on the surveyed data of 326 participants, revealed that prosocial sharing intention is affected by protecting factors (i.e., sharing efficacy, response efficacy) and helping factors (i.e., reciprocity expectation). Additionally, both perceived health risk and perceived information quality risk were found to influence the sharing intention via motivational factors

DNA Hypermethylation in Breast Cancer

Cancer development is a complex process with multiple steps. Many factors, including radiation, chemicals, viruses, genetic and epigenetic changes, lead to abnormal proliferation of a single cell, which results in the outgrowth of a population of clonal-derived tumour cells. It has established that DNA hypermethylation, an epigenetic mechanism that occurred by the addition of a methyl group at 5′ position of the pyrimidine ring of cytosine residues at CpG islands through the action of DNA methyltransferase enzymes, has been considered as the cause of human tumorigenesis, including breast cancer development. Moreover, DNA hypermethylation holds a promising application as a potential biomarker for the early detection, prognosis and prediction of drug sensitivity in cancer. Therefore, this chapter focuses on the description and exemplification of the DNA hypermethylation changes, particularly, highlight the DNA hypermethylation as a potential biomarker applied in predictive, diagnostic, prognostic and therapeutic monitoring of breast cancer

IDENTIFICATION OF FREQUENT PROMOTER METHYLATION OF DEATH-ASSOCIATED PROTEIN KINASE IN LIQUID-BASED PAPANICOLAOUS TEST SAMPLES IN VIETNAMESE POPULATION

  Objective: The infection of high-risk human papillomavirus (HPV) genotypes, particularly HPV-16 and HPV-18, is known to cause cervical cancer (CC); however, aberrant DNA methylation of death-associated protein kinase (DAPK), a member of tumor suppressor gene family, are required for cervical tumorigenesis. The aim of our study was to evaluate the hypermethylation frequency of CpG belonged to DAPK promoter, in Vietnamese patients, as well as to study about the association between hypermethylation, and high-risk HPV infection leading to CC.Methods: Methylation-specific-polymerase chain reaction (MSP) was performed to analyze methylation status from 109 liquid-based papanicolaous test samples, collected from local hospital and were identified whether HPV/or non-HPV, high-risk/low-risk HPV infection, then was confirmed by sequencing.Results: In the case of high-risk HPV infection, the frequency of DAPK gene hypermethylation was 66.67% (24 of 36 cases). Meanwhile, low hypermethylation status was found in low-risk and non-HPV infection, counting for 12.0% (3 of 25 cases), 2.1% (1 of 48 cases), respectively. Significant association of DAPK hypermethylation with high-risk, low-risk, and non-HPV infection was observed (p<0.0001). The DAPK hypermethylation increased the possibility to CC in the case of high-risk HPV infected with high incidence: Odds ratio=34.5 (95% confidence interval [CI]=10.15-117.23, p<0.01), relative risk=12.2 (95% CI=4.56-32.42, p<0.01).Conclusion: Based on those data, it suggested that MSP carried out on noninvasive samples will lead to potential method to screening, diagnosis and early diagnosis of cervical carcinoma in Vietnamese population